| 1981 | First private hospital in Australia to establish an Intensive Care facility |
| 1989 | First fully computerised Sleep Disorders Unit in Australia
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| 1989 | First private Emergency Department accredited to accept time critical medical patients |
| 1989 | First private Renal Dialysis Unit |
| 1996 | First Stroke Unit in a private hospital in Victoria |
| 1997 | First private hospital in Victoria to appoint a GP Coordinator |
| 2000 | First medically managed Hospital in the Home Unit in a private hospital in Australia |
| 2000 | First pacemaker lead extraction using laser therapy |
| 2002 | First dedicated electrophysiology laboratory opened in Victoria's health system |
| 2003 | first aboveground radiotherapy centre in Australia. Tattersalls Cancer Centre opened at Epworth in partnership with Peter Mac |
| 2003 | First hospital in southern hemisphere to use Image Guided Radiation Therapy |
| 2003 | Epworth introduces first Da Vinci Robotic assisted surgery to Australia |
| 2003 | Epworth opens the first private sector Medical Observation Unit in Victoria |
2003
| Three 'world first' vascular procedures are carried out at Epworth's Vascular Laboratory: 1. Insertion of a large diameter stent (Express Vascular Large Diameter Stent) 2. Ultrasonic thrombolysis trialled at Epworth 3. Use of a new abdominal aortic aneurysm polymer repair device |
| 2005 | Australia's most modern hospital, Epworth Eastern at Box Hill, is completed and was officially opened by the Federal Health Minister, Tony Abbott on August 2nd |
| | The new Acquired Brain Injury Unit (ABI) opens in Richmond. |
| | Epworth acquires Epworth Freemasons – one of Melbourne’s premier maternity hospitals. |
| 2006 | Epworth purchases Cedar Court Rehabilitation Hospital to become Epworth Rehabilitation Camberwell, further expanding its rehabilitation services.
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| 2007 | Federal Treasurer Peter Costello acknowledges Mia Templeton born 29 June at Epworth Freemasons as the 21 millionth Australian. |
| 2009 | Epworth goes global and signs a formal affiliation agreement with the prestigious Cleveland Clinic and a program of international training of registrars and surgical fellows begins. |
| | The Yarra City Council approved a $350 million redevelopment of the Richmond Hospital site. |
| 2010 | Epworth celebrates its 90th birthday, with a series of events and the publication of its history. |
| | Epworth acquired the assets of Cliveden Hill Private Hospital in East Melbourne, now known as Epworth Cliveden. |
| 2011 | A team from Epworth Richmond wins first prize in the Australian Private Hospitals Association inaugural Valuing Private Hospital Staff Awards for Team Excellence. |
| | Epworth HealthCare and Deakin University sign an agreement to build a private teaching hospital at the Waurn Ponds campus in Geelong. |